# Contact

Mail. radmoore@gmail.com
Web. https://radm.info
Cell. +49.177.4048796
Jabber. radmoore@gmail.com

79AC 86D9 B27A F2DE 4C85 3171 354A 9731 4CC2 0059
Public key

# Research

In my former life I did my PhD in Bioinformatics and worked as a research scientist in the Evolutionary Bioinformatics Group at the IEB in Muenster, Germany. My research was focused on aspects of molecular evolution. In particular, a prime focus of my research was to understand how domains, the structual and functional components of proteins, are used as recombination 'modules' forming the diverse protein functionalities which can be observed in nature. Beyond domain combinations, I explored the formation of new domains, and studied the impact of new domains on the functional repertoire. My research utilized methods of comparative genomics to reconstruct the evolution of proteins and to help provide a quantitative model of modular protein evolution. Furthermore, I developed a number of computational tools to aid the analysis of modular evolution, and sequence anaylsis in general. Beyond modular evolution, I worked on methods for conducting over-representation analysis of Gene Ontology terms (and their visualization).

Currently, I work in the RnD IT for Bayer, after working a bit over two years for a division of Abbott Diagnostics (Abbott Informatics).

# Selected Projects

Most of the projects below are only marginally active. If somebody is interested in using or wants to contribute / extend / continue drop me a note. For a more complete list, visit https://github.com/radmoore

A Ruby API for modelling protein evolution

A simple Ruby API for creating and traversing tree data structures

A powerful suite of tools for the analysis of protein family evolution. Written in Java
A tool for gene ontology simplification. Written in Java with A. Held.
PfamScanner is a threaded wrapper utility for HMMER (hmmscan). It provides a number of post-processing tools and produces XDOM output. Written in Java.

A web application for athletes
RadScan is a Java command line utility for performing domain achitecture-based similarity searches against UniProt

A text-based progress bar for Java

# Publications

Journal Articles
A.D. Moore, A. Held, N. Terrapon, J. Weiner, E. Bornberg-Bauer
DoMosaics: Software for domain arrangement visualization and domain-centric analysis of proteins
Bioinformatics, 30(2):282-283 (2014)

N. Terrapon, J. Weiner, S. Grath, A. D. Moore, and E. Bornberg-Bauer
Rapid similarity search of proteins using alignments of domain arrangements
Bioinformatics, 30(2):274-281 (2014)

A. D. Moore, S. Grath, A. Schüler, A. K. Huylmans, and E. Bornberg-Bauer
Quantification and Functional Analysis of Modular Protein Evolution in a Dense Phylogenetic Tree
Biochimica et Biophysica Acta, 1834(5):898-907 (2013)

A. Reineke, E. Bornberg-Bauser, A. D. Moore, and Sonja Grath
Dynamics and adaptive benefits of protein domain emergence and arrangements during plant genome evolution
Genome Biol Evol., 4(3):316-329 (2012)

A. D. Moore and E. Bornberg-Bauer
The Dynamics and Evolutionary Potential of Domain Loss and Emergence
Mol Biol Evol., 29(2): 787-796 (2012)

The Nasonia Genome Working Group
Functional and evolutionary insights from the genomes of three parasitoid Nasonia species
Science, 327:5963 (2010)

L. Wissler, E. Dattolo, A. D. Moore, T. B. H. Reusch, J. L. Olsen, M. Migliaccio, E. Bornberg-Bauer, G. Procaccini
Dr. Zompo: an online data repository for Zostera marina and Posidonia oceanica ESTs
Database, doi: 10.1093/database/bap009 (2009)

A. D. Moore, A. K Bjoerklund, D. Ekman, E. Bornberg-Bauer and A. Elofsson
Arrangements in the Modular Evolution of Proteins
Trends Biochem Sci, 33:9 (2008)

J. Weiner 3rd, A. D. Moore, E. Bornberg-Bauer
Just how versatile are domains?
BMC Evolutionary Biology, 8:285 (2008)

Book chapters
A. D. Moore and E. Bornberg-Bauer
Protein domains as evolutionary units
in: Evolutionary Genomics and Systems Biology, Ed. G. Caetano-Anollés (2010)
John Wiley & Sons

Published abstracts / Proceedings
A. D. Moore, A. Held, N. Terrapon, J. Weiner, and E. Bornberg-Bauer
Visualize and study proteins via domain arrangement with DoMosaics
Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM), Rennes (France), 2013
(French, written by N. Terrapon)

A. D. Moore and E. Bornberg-Bauer
Footprints of modular evolution in a dense taxonomic clade
GCB 2012 Highlight Abstracts, Jena (Germany), 2012

N. Terrapon, S. Grath, J. Weiner, A. D. Moore, and E. Bornberg-Bauer
Fast Homology Search Using Domain-Architecture Alignment
Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM), Rennes (France), 2012

# Conferences contributions

German Conference on Bioinformatics
Highlight paper selected as oral presentation
Jena (Germany), September 19-22, 2012

5th Annual Genomics Symposium
Poster abstract selected as oral presentation; presented by Sonja Grath
Kansas City (USA), June 9-12, 2011

Interdisciplinary Graduate Students Symposium evolution across fields
Lighting talk
Münster (GER), February 17-18, 2011

3rd Annual Arthropod Genomics Symposium
Poster contribution
Kansas City (USA), June 11-14, 2009

Evolution across scales
Poster contribution
Potsdam (GER), May 26-28, 2008
Sponsered by The Volkswagen Foundation

Advanced Protein Domain Analysis Training Workshop
Lyon (FRA), May 18-20, 2008
Sponsered by Embrace

Halifax (CDN), June 24-28, 2007

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2014-2019 | Andrew Moore